Monthly Archives: October 2009

OA week webina: China's illy defined scientific journal policy

Nature Network博客上的原文:http://network.nature.com/people/andrewsun/blog/2009/10/20/oa-week-webina-chinas-illy-defined-scientific-journal-policy

On 9:45 Tusday GMT+8 a webina was organized by Zhiming Wang, editor of Nanoscale Research Letters. In the webina Patrick Brown, director of PLoS, gave a talk to the Chinese audience on the OA strategy and the single paper metrics feature of PLoS website.

A surely relevant topic of the survival and development of any journal is the highness of its ‘impact’. Highly concerned by Chinese effort to boost the development of local scientific journals, Patrick criticized strongly, agreed by all Chinese audience, on the ill institution of current Chinese science policy and its destructive effect on journals. In China, number of papers published on higher-impact journals is linked with the promotion and funding of the authors, that is, personal interest. This renders journals with additional economical status, either favorable or unfavorable determined by their “highness of impact”, because personal interest is never met for free in a free market society. An invisible bargain exist between every pair of journal and authorship. By “highness of impact”, one means simply impact factor in China. This, as mentioned by Patrick, conducts a “very destructive punishment” for all new journals, including esp. OA ones. Journals don’t have ISI impact factors for at least two years even they have been indexed. Some journals with ‘experimental’ way of peer-review or distribution process are even not indexed by ISI (e.g. PLoS one). Under China’s current reality, authors get punished if they publish their results on these journals. I wondered how many submission from China does PloS one received each year compared with other non-OA, ISI indexed journals. Patrick had to look up a bit but he answered that in general China ranks almost the lowest in publishing on new journals.

Although the single-paper metrics feature of PLoS journals can be a better alternative to the impact factor of the whole journal when it comes to grading a person in science community, the reason behind the ill policy is much more general and is also influencing other scientific process badly in China; evaluation of a person or institute’s scientific achievement is still to a large extent not conducted by peers but general, ‘macroscopic’, administrative roles, who have nothing more to rely on except quantitative measurements such as numbers of paper, ISI impact factors, h-index. Instead of only referring to the advantage of these measures, they rely on the whole of them including their negative effects which are surely larger.

An atmosphere that appreciates the status of scientific peers, either administrative and cultural, is highly needed, which though is not possible in the current state of education system of China.

期刊博文:我导师关于期刊的“卖空调”理论以及我的演绎

最近组里一个身在国外的同学之前投Langmuir的一篇东西发回来审稿意见了,有一个关键的图精度不够,“达不到Langmuir的要求”。我等在国内的同学需要帮他重做测试补数据。

我导师说,人家卖贵的空调,其他不说,但总之不会有很吵的。你的空调很吵,虽然也是空调,也没造假没人偷工减料,但就是上不了档次,不符合国美的要求,就不能拿到国美卖,只能地摊上卖。”

所以,如果你买很差的仪器,实验要求一旦稍高一点数据就精度不够,你就总是发不了高档次文章。所以,买什么仪器都花钱买大名牌很大程度上是这方面考虑。然后,文章档次“被关联”到人的经费升迁利益,因此,名牌仪器厂商当然要卖贵一点儿,双赢嘛!又所以,如果买了贵仪器,还发不了什么好文章,那你就真的是菜的n次方!

所以,为什么很大一部分牛组的仪器DIY程度很高。Commercial available的仪器尚且有钱就能买得到,这些牛组甚至在测试手段上都领先了,有从理论上垄断了新发现的可能,有可能不牛吗?

所以中国的研究人员如果只懂买仪器,按照仪器说明书和软件所提供的功能按按钮操作,是永远不可能领先的。事实上科研仪器的功能都是从以往基础研究的Idea中提取出来的。有这个功能就说明有人这么做过了。你用现成功能,你的实验就首先不可能在方法上有什么新意,在发现上的新意也很有限——你只会发现那些已有方法应该能发现的东西。

很多同学认为GPC是测分子量的,动态光散射是测粒径的。我导师极其不爽这一点。一定要记住:GPC是测流出时间的,动态光散射是测光散射的!——加个“动态”只是代表了数据收集和数学处理方法。流变仪是测形变和转矩的!甚至要认识到,所有用电,连接电脑的仪器都是测电流或者电压的!一台测电压的东东你怎么会算出分子量?你不知道你干嘛用?还发文章?

从这个角度看,中国研究人员的水平需要提高。但是,目前水平对于发文章来讲貌似显不出什么必要性。拿GPC测分子量和拿动态光散射测粒径好像问题都不大。但是,如果对于审稿工作来说,这种水平就太差了!如果我们的作者总是GPC测分子量,光散射测粒径,审稿人也相信GPC的分子量,光散射的粒径。那我们就算再忠诚地投中文期刊,中国人的研究永远也不会入流。

不过,中国科研人员的工作目的显然不是为了让中国人的研究入流甚至一流,而是为了生计。发文章是求人发工钱,审稿审基金就是看人给工钱。整个事情就算不说是“权钱交易”(别那么愤青),也主要是一堆下面的人为了满足国家科研强国的梦想糊弄了事。你告诉他水平差,他一点都不着急。有什么办法?

没有好的审稿人,我们中国就办不出“国美”,“好空调”就不会放中文期刊里卖,卖的只有很吵的空调。是不是空调?是。有没有造假抄袭?就当没有吧。几流?n流。

我总觉得外国人是天生愿意研究科学的,中国人是被逼的——不然坚船利炮就哇哇哇打过来了。所以我们很强调“科研强国”嘛。人家当然也提科研强国,因为这是事实上有效的。但人家不是一开始就科研强国来着。我们是挨完打,带着屈辱和“崛起”的梦想引入科学的,事实上啥能强国咱就引入啥,机会主义得很。引入科学在主观上并不是什么必然。

我有几年暑假连续下乡义教,发现山区的穷孩子确实很渴望念书,但他们是为了改变命运。所以一旦社会多元化,读书不包分配之后,马上就盛行“读书无用论”。他们对念书,一会儿渴望得让你心痛;转眼又鄙夷得让你心寒。所以我们下乡的义工从来不跟他们贯输什么“改变贫穷、改变命运”的破道理。我们只讲有趣的知识,第二课堂。读书的渴望本应来知识的魅力。

科学研究也一样。因此我们国家可以说是科研穷国,我们的科研人员是穷孩子。一会儿抱着“改变命运”的理想狂搞;一会儿又盛行“科学无用论”,带着虚无主义混饭吃,抄袭剽窃偶尔为之。这就是穷!别以为花得起钱买动态光散射你就很富。

捡起一粒细菌

Cell Force Spectroscopy

Cell Force Spectroscopy

已经发表在9月份《新知客》专栏,切务转载。

ResearchBlogging.org

如果让你从地上捡起一枚硬币,你一定会用双指将其夹起。如果有人只用一指,想通过指上的手汗把硬币粘起来,将会显得很傻,且必将失败。但是,科学家若想要捡起一粒细菌的话,就不得不干这样的傻事,不过倒是挺成功的。

细菌就跟一个细胞大小差不多,它无非比我们人体的细胞独立一点,“一个人”也能生活。所以它太小了,肉眼看不见,要在显微镜下才能捡起它。细菌又很粘,它的细胞壁上有很多粘性分子,抓着附着的表面不放。它还很弱,你使点儿劲吧,就把它捏破了。所以科学家要捡起一粒细菌,不能像平时捡硬币那样用捏,只能用粘。细菌粘附力再强,不会强过自身的撕烈强度。

为了把细菌粘起来,科学家想了很多办法。直接拿一个小东西(通常是硅化合物材料)去粘细菌,有时还粘不上来,需要涂上点“胶水”。各种胶水都试过,但有很多对细菌来说是有影响的。有的胶水会使细菌“昏迷”,有的会直接把它药死。细菌都死了,就没有研究意义了。所以要采用不影响细菌活性的胶水。为了保持细菌存活,整个操作当然也要营养液中进行。

科学家捡起一个细菌来都研究什么呢?从上世纪九十年代首次有人捡细菌开始到现在,大家主要都是就便研究细菌和其他生物体细胞的粘附行为,看看这些小生命的力气怎么样,喜欢什么表面,讨厌什么表面。凝血和血栓的形成,就是因为血红细胞壁上的化学成分发生了变化,容易粘成一团的缘故。癌的扩散,也跟癌细胞的脱落和粘附有关。因此,研究单细胞的粘附性质意义是不小的。当然,将来这种捡细菌的技术可能还会用来帮细胞“排队”,实现更多意想不到的事情。

Kang, S., & Elimelech, M. (2009). Bioinspired Single Bacterial Cell Force Spectroscopy Langmuir, 25 (17), 9656-9659 DOI: 10.1021/la902247w